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Olivier, Michael
One or more keywords matched the following properties of Olivier, Michael
PropertyValue
keywords Mass Spectrometry
keywords Next Generation Sequencing
overview My laboratory uses a wide range of genomics, proteomics, metabolomics and bioinformatics tools to study the molecular basis of common human diseases. We routinely use next generation sequencing, gene expression analysis, and mass spectrometry to profile cells and tissues from human patients and animal models to identify early molecular changes that happen in target tissues and organs during the initial development of diseases such as obesity, cardiovascular diseases, or dylipidemias and fatty liver disease. Our lab group has been developing novel methodologies to functionally study human genome variation, and to help understand how mutations and sequence variants that have been identified in large scale genetic studies (e.g. genome-wide association studies) actually affect the normal function of cells. Work in our lab ranges from basic molecular biology to tissue culture, high-end sequencing and mass spectrometry, and computational data analysis.
One or more keywords matched the following items that are connected to Olivier, Michael
Item TypeName
Academic Article Obesity and its therapy: from genes to community action.
Academic Article Genetic variation in the peroxisome proliferator activated receptor-gamma gene is associated with histologically advanced NAFLD.
Concept Sequence Analysis, RNA
Concept Oxidative Stress
Concept Particle Size
Concept Down Syndrome
Concept Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Concept Lod Score
Concept Genome, Human
Concept Hearing Loss, Sensorineural
Concept Binding Sites
Concept Saccharomyces cerevisiae Proteins
Concept Sex-Determining Region Y Protein
Concept Computer Simulation
Concept Statistics as Topic
Concept Amino Acid Sequence
Concept Saccharomyces cerevisiae
Concept Gas Chromatography-Mass Spectrometry
Concept Cohort Studies
Concept Polycystic Ovary Syndrome
Concept Genetic Loci
Concept Reference Standards
Concept Spectrometry, Mass, Electrospray Ionization
Concept Serum
Concept Intercellular Signaling Peptides and Proteins
Concept Organ Specificity
Concept Agouti Signaling Protein
Concept Consensus Sequence
Concept Neonatal Screening
Concept Species Specificity
Concept Gene Expression Profiling
Concept Tandem Mass Spectrometry
Concept Blotting, Southern
Concept Sequence Analysis, DNA
Concept RNA, Small Interfering
Concept Genetic Association Studies
Concept Software
Concept Neoplastic Stem Cells
Concept Multigene Family
Concept Sequence Tagged Sites
Concept Rats, Inbred Strains
Concept Body Size
Concept Epistasis, Genetic
Concept Polymorphism, Single Nucleotide
Concept Sensitivity and Specificity
Concept Genes, Dominant
Concept Quantitative Trait Loci
Concept Sirtuins
Concept Case-Control Studies
Concept Chromosome Segregation
Concept Prospective Studies
Concept Staining and Labeling
Concept Substrate Specificity
Concept Genome-Wide Association Study
Concept Melanocyte-Stimulating Hormones
Concept Gene Components
Concept Oligonucleotide Array Sequence Analysis
Concept Rats, Sprague-Dawley
Concept Sodium Chloride, Dietary
Concept In Situ Hybridization, Fluorescence
Concept Base Sequence
Concept Alleles
Concept Molecular Sequence Data
Academic Article Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation.
Academic Article Nonhuman Primates and Translational Research-Cardiovascular Disease.
Academic Article Proteomics in non-human primates: utilizing RNA-Seq data to improve protein identification by mass spectrometry in vervet monkeys.
Academic Article HyCCAPP as a tool to characterize promoter DNA-protein interactions in Saccharomyces cerevisiae.
Academic Article Advanced methods for the analysis of chromatin-associated proteins.
Academic Article Discovery of Chromatin-Associated Proteins via Sequence-Specific Capture and Mass Spectrometric Protein Identification in Saccharomyces cerevisiae.
Award or Honor Receipt Charles J. Epstein Research Award
Grant Candidate Genes Affecting Adolescent Metabolic Syndrome
Grant National Heart, Lung, and Blood Institute Proteomics Initiative
Grant Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
Grant Functional characterization of regulatory sequence variants in complex diseases
Grant Wisconsin Center of Excellence in Genomics Science
Grant Genomic dissection of a QTL affecting the lipid profile
Academic Article Putting the Invader assay to work: laboratory application and data management.
Academic Article Improved method for the analysis of membrane proteins by mass spectrometry.
Academic Article A haplotype map of the human genome.
Academic Article 18O labeling over a coffee break: a rapid strategy for quantitative proteomics.
Academic Article An outcrossed canine pedigree for linkage analysis of hip dysplasia.
Academic Article Insights into Dahl salt-sensitive hypertension revealed by temporal patterns of renal medullary gene expression.
Academic Article Current analysis platforms and methods for detecting copy number variation.
Academic Article Linkage and association between distinct variants of the APOA1/C3/A4/A5 gene cluster and familial combined hyperlipidemia.
Academic Article Obesity-related dyslipidemia associated with FAAH, independent of insulin response, in multigenerational families of Northern European descent.
Academic Article Localization and characterization of nucleotide sequences from the canine Y chromosome.
Academic Article Genetic linkage and association of the growth hormone secretagogue receptor (ghrelin receptor) gene in human obesity.
Academic Article The rocky road toward clinical genetic testing: insights into the physio-genetic basis of hearing loss.
Academic Article Integrated approach for the comprehensive characterization of lipoproteins from human plasma using FPLC and nano-HPLC-tandem mass spectrometry.
Academic Article The Invader assay for SNP genotyping.
Academic Article Genetic determinants of obesity-related lipid traits.
Academic Article Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.
Academic Article Single nucleotide polymorphisms in protein tyrosine phosphatase 1beta (PTPN1) are associated with essential hypertension and obesity.
Academic Article Accounting for a quantitative trait locus for plasma triglyceride levels: utilization of variants in multiple genes.
Academic Article Tree-structured supervised learning and the genetics of hypertension.
Academic Article A novel method, the Variant Impact On Linkage Effect Test (VIOLET), leads to improved identification of causal variants in linkage regions.
Academic Article Integration of cytogenetic landmarks into the draft sequence of the human genome.
Academic Article Automated SNP genotype clustering algorithm to improve data completeness in high-throughput SNP genotyping datasets from custom arrays.
Academic Article Two DNA sequences specific for the canine Y chromosome.
Academic Article Methods and approaches for the comprehensive characterization and quantification of cellular proteomes using mass spectrometry.
Academic Article Linkage and segregation analysis of black and brindle coat color in domestic dogs.
Academic Article Radiation hybrid mapping with BAC ends.
Academic Article Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides.
Academic Article Identification of cell surface markers to differentiate rat endothelial and fibroblast cells using lectin arrays and LC-ESI-MS/MS.
Academic Article Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index.
Academic Article Fatty acid binding protein 3 (fabp3) is associated with insulin, lipids and cardiovascular phenotypes of the metabolic syndrome through epigenetic modifications in a Northern European family population.
Academic Article Haplotype analysis of the apolipoprotein gene cluster on human chromosome 11.
Academic Article Parallel single nucleotide polymorphism genotyping by surface invasive cleavage with universal detection.
Academic Article Quantitative comparison of lipoprotein fractions derived from human plasma and serum by liquid chromatography-tandem mass spectrometry.
Academic Article Characterization of vascular endothelial growth factor receptors on the endothelial cell surface during hypoxia using whole cell binding arrays.
Academic Article Association of TMTC2 With Human Nonsyndromic Sensorineural Hearing Loss.
Academic Article From SNPs to function: the effect of sequence variation on gene expression. Focus on "a survey of genetic and epigenetic variation affecting human gene expression".
Academic Article Exclusion of melanocortin-1 receptor (mc1r) and agouti as candidates for dominant black in dogs.
Academic Article A high-resolution radiation hybrid map of the human genome draft sequence.
Academic Article Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels.
Academic Article ZoomQuant: an application for the quantitation of stable isotope labeled peptides.
Academic Article Sequential abundant ion fragmentation analysis (SAIFA): an alternative approach for phosphopeptide identification using an ion trap mass spectrometer.
Academic Article Relative quantification of peptide phosphorylation in a complex mixture using 18O labeling.
Academic Article Variant discovery in targeted resequencing using whole genome amplified DNA.
Academic Article Random amplified polymorphic DNA (RAPD) sequences as markers for canine genetic studies.
Academic Article Hepatic gene networks in morbidly obese patients with nonalcoholic fatty liver disease.
Academic Article Proteomic characterization of high-density lipoprotein particles in patients with non-alcoholic fatty liver disease.
Academic Article Sequence-specific capture of protein-DNA complexes for mass spectrometric protein identification.
Academic Article A comprehensive analysis of adiponectin QTLs using SNP association, SNP cis-effects on peripheral blood gene expression and gene expression correlation identified novel metabolic syndrome (MetS) genes with potential role in carcinogenesis and systemic inflammation.
Academic Article Analysis of concordance of different haplotype block partitioning algorithms.
Academic Article Corrigendum: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.
Academic Article High-throughput genotyping of single nucleotide polymorphisms using new biplex invader technology.
Academic Article To understand the whole, you must know the parts: unraveling the roles of protein-DNA interactions in genome regulation.
Academic Article A novel procedure for genotyping of single nucleotide polymorphisms in trisomy with genomic DNA and the invader assay.
Academic Article Simultaneous quantification and identification using 18O labeling with an ion trap mass spectrometer and the analysis software application "ZoomQuant".
Academic Article Body fat distribution, lipoprotein metabolism, and insulin resistance: a lifetime of research on the pathophysiology of the human metabolic syndrome.
Academic Article Gene expression reveals vulnerability to oxidative stress and interstitial fibrosis of renal outer medulla to nonhypertensive elevations of ANG II.
Academic Article Genomic and geographic distribution of private SNPs and pathways in human populations.
Academic Article Effects of Lifetime Occupational Pesticide Exposure on Postural Control Among Farmworkers and Non-Farmworkers.
Academic Article Adaptation of Hybridization Capture of Chromatin-associated Proteins for Proteomics to Mammalian Cells.
Academic Article High-resolution gas chromatography/mass spectrometry metabolomics of non-human primate serum.
Grant Womb to Tomb: Developmental Programming and Aging Interactions in Primates
Grant HyCCAPP: A new method for the functional analysis of regulatory SNPs
Academic Article Analysis of serum changes in response to a high fat high cholesterol diet challenge reveals metabolic biomarkers of atherosclerosis.
Academic Article Optimized GC-MS metabolomics for the analysis of kidney tissue metabolites.
Academic Article Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2?T-type voltage-gated calcium channels and Ca2+ influx.
Grant Integrated Omics Analysis of Pain: Omics Data Generation Center
Academic Article The Need for Multi-Omics Biomarker Signatures in Precision Medicine.
Award or Honor Receipt Research Excellence Award
Award or Honor Receipt Research Excellence Award
Academic Article Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet.
Academic Article Efficiency of whole-exome sequencing in old world and new world primates using human capture reagents.
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